Stephen L Leib Selected Research

Dexamethasone (Maxidex)

8/2018	Combined effect of non-bacteriolytic antibiotic and inhibition of matrix metalloproteinases prevents brain injury and preserves learning, memory and hearing function in experimental paediatric pneumococcal meningitis.
1/2016	Inhibition of Hippocampal Regeneration by Adjuvant Dexamethasone in Experimental Infant Rat Pneumococcal Meningitis.
3/2011	Adjunctive dexamethasone affects the expression of genes related to inflammation, neurogenesis and apoptosis in infant rat pneumococcal meningitis.
9/2007	Limited efficacy of adjuvant therapy with dexamethasone in preventing hearing loss due to experimental pneumococcal meningitis in the infant rat.
4/2006	Strategies to prevent neuronal damage in paediatric bacterial meningitis.

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Stephen L Leib Research Topics

Disease

51	Pneumococcal Meningitis (Streptococcus pneumoniae Meningitis) 05/2023 - 09/2002
39	Infections 01/2023 - 07/2002
24	Meningitis 05/2023 - 06/2002
24	Bacterial Meningitis 05/2023 - 06/2002
20	Inflammation (Inflammations) 01/2020 - 09/2002
15	Brain Injuries (Brain Injury) 07/2020 - 01/2005
8	Hearing Loss (Hearing Impairment) 07/2019 - 07/2006
7	Neuroinflammatory Diseases 01/2022 - 08/2018
6	Meningococcal Meningitis 07/2020 - 04/2006
6	Necrosis 07/2019 - 06/2002
5	Pneumococcal Infections 04/2024 - 01/2016
5	Multiple Sclerosis 06/2022 - 05/2008
5	Body Weight (Weight, Body) 01/2020 - 06/2007
5	Heart Arrest (Cardiac Arrest) 01/2020 - 01/2015
3	Pneumonia (Pneumonitis) 01/2022 - 11/2019
3	Bacterial Infections (Bacterial Infection) 01/2020 - 12/2009
3	Weight Loss (Weight Reduction) 01/2019 - 04/2014
2	COVID-19 06/2022 - 01/2022
2	Stroke (Strokes) 01/2022 - 03/2016
2	Ischemic Stroke 01/2022 - 01/2021
2	Brain Ischemia (Cerebral Ischemia) 01/2022 - 01/2020
2	Ventilator-Associated Pneumonia 09/2021 - 11/2019
2	Thrombosis (Thrombus) 01/2021 - 10/2019
2	Aneurysm (Aneurysms) 01/2021 - 10/2019
2	Neointima 01/2021 - 10/2019
2	Alveolar echinococcosis 01/2021 - 05/2015
2	Communicable Diseases (Infectious Diseases) 08/2019 - 04/2011
2	Central Nervous System Infections (Central Nervous System Infection) 01/2018 - 01/2007
2	Hemorrhage 03/2016 - 12/2014
2	Virus Diseases (Viral Diseases) 03/2016 - 05/2013
2	Bacteremia 05/2014 - 01/2010
2	Seizures (Absence Seizure) 01/2008 - 09/2003
1	Dysbiosis 04/2024
1	Asymptomatic Infections 01/2023
1	Bites and Stings (Sting) 01/2023
1	Aspergillosis 01/2022

Drug/Important Bio-Agent (IBA)

17	Anti-Bacterial Agents (Antibiotics)IBA 04/2024 - 04/2006
13	Ceftriaxone (Ceftriaxon)FDA LinkGeneric 05/2023 - 07/2006
12	Matrix Metalloproteinases (MMPs)IBA 07/2020 - 06/2002
11	Proteins (Proteins, Gene)FDA Link 12/2017 - 07/2002
10	CytokinesIBA 01/2022 - 07/2008
8	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 01/2022 - 05/2003
8	EnzymesIBA 03/2015 - 06/2002
6	Daptomycin FDA Link 09/2021 - 06/2007
6	Matrix Metalloproteinase 9 (Gelatinase B)IBA 03/2010 - 12/2002
5	Dexamethasone (Maxidex)FDA LinkGeneric 08/2018 - 04/2006
5	Reactive Oxygen Species (Oxygen Radicals)IBA 12/2017 - 06/2002
5	Interleukin-6 (Interleukin 6)IBA 03/2016 - 01/2013
5	KynurenineIBA 10/2014 - 11/2006
5	VaccinesIBA 03/2013 - 10/2009
4	AntigensIBA 01/2022 - 10/2009
4	Neuroprotective AgentsIBA 07/2020 - 08/2013
4	Matrix Metalloproteinase InhibitorsIBA 07/2020 - 01/2014
3	Streptococcus pneumoniae plY proteinIBA 04/2024 - 05/2019
3	Immunoglobulin G (IgG)IBA 01/2023 - 01/2022
3	Messenger RNA (mRNA)IBA 06/2022 - 11/2006
3	AntibodiesIBA 01/2022 - 01/2010
3	Liposomes (Liposome)IBA 01/2022 - 01/2016
3	Biomarkers (Surrogate Marker)IBA 10/2020 - 12/2014
3	Doxycycline (Periostat)FDA LinkGeneric 07/2020 - 07/2006
3	Brain-Derived Neurotrophic Factor (BDNF)IBA 08/2013 - 01/2005
3	CathelicidinsIBA 02/2011 - 11/2008
3	Antimicrobial PeptidesIBA 02/2011 - 11/2008
3	AntioxidantsIBA 04/2006 - 07/2002
2	Penicillins (Penicillin)FDA Link 05/2023 - 01/2018
2	Interleukin-1beta (Interleukin 1 beta)IBA 01/2022 - 07/2003
2	galactomannanIBA 01/2022 - 10/2007
2	Aspirin (Acetylsalicylic Acid)FDA LinkGeneric 01/2021 - 10/2019
2	batimastat (BB 94)IBA 07/2020 - 12/2014
2	ChemokinesIBA 01/2020 - 07/2013
2	Metalloproteases (Metalloproteinases)IBA 08/2019 - 01/2014
2	Vitamin B 6IBA 12/2017 - 08/2013
2	Potassium Chloride FDA LinkGeneric 04/2016 - 01/2015
2	esmolol (Brevibloc)FDA LinkGeneric 04/2016 - 01/2015
2	CollagenIBA 03/2016 - 04/2014
2	Interleukin 1 Receptor Antagonist Protein (Anakinra)FDA Link 07/2013 - 01/2013
2	Caspase 3 (Caspase-3)IBA 02/2013 - 05/2003
2	salicylhydroxamic acid (SHAM)IBA 03/2011 - 01/2009
2	Toll-Like Receptor 2IBA 01/2009 - 04/2007
2	CaspasesIBA 10/2008 - 05/2003
2	Atorvastatin (Lipitor)FDA Link 07/2008 - 05/2008
2	Interferon-betaIBA 07/2008 - 05/2008
2	Tissue Inhibitor of Metalloproteinase-1IBA 05/2008 - 03/2006
2	N-Methyl-D-Aspartate Receptors (NMDA Receptors)IBA 01/2008 - 09/2003
2	N-Methylaspartate (NMDA)IBA 01/2008 - 09/2003
2	ADAM17 ProteinIBA 04/2007 - 07/2006
2	Collagen Type IV (Type IV Collagen)IBA 12/2006 - 03/2006
1	Peptides (Polypeptides)IBA 04/2024
1	AerosolsIBA 01/2023
1	2019-nCoV Vaccine mRNA-1273IBA 06/2022
1	BNT162 VaccineIBA 06/2022
1	mRNA VaccinesIBA 06/2022
1	Caspofungin (Cancidas)FDA Link 01/2022
1	Indicators and Reagents (Reagents)IBA 01/2022
1	endolysinIBA 01/2022

Therapy/Procedure

27	Therapeutics 01/2022 - 06/2002
4	Phage Therapy 01/2022 - 11/2019
2	Stents 01/2021 - 10/2019
2	Resuscitation 01/2020 - 04/2016
1	Intraperitoneal Injections 01/2022